Canada Gazette, Part I, Volume 146, Number 41: GOVERNMENT NOTICES

October 13, 2012

DEPARTMENT OF HEALTH

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

Proposed residential indoor air quality guideline for naphthalene

Pursuant to subsection 55(3) of the Canadian Environmental Protection Act, 1999, the Minister of Health hereby gives notice of a proposed residential indoor air quality guideline for naphthalene. The following exposure limit is proposed:
Exposure period	Concentration
Exposure period	µg/m³	ppb
Long-term	10	1.9

Health Canada recommends reducing exposure to naphthalene as much as possible, in order to minimize the risk of cancer, by controlling or removing sources of naphthalene in your home.

Any person may, within 60 days after publication of this notice, file with the Minister of Health written comments on the proposed guideline. All written comments are to be made publicly available to all interested parties. All comments, requests for copies of the full science assessment, and information requests must cite the Canada Gazette, Part Ⅰ, and the date of publication of this notice and be sent to the Water, Air and Climate Change Bureau, Health Canada, 269 Laurier Avenue W, Ottawa, Ontario K1A 0K9, 613-957-1876 (telephone), 613-948-8482 (fax), air@hc-sc.gc.ca (email).

September 25, 2012

KAREN LLOYD
Director General
Safe Environments Directorate
On behalf of the Minister of Health

PROPOSED RESIDENTIAL INDOOR AIR QUALITY GUIDELINE FOR NAPHTHALENE

Physical and chemical properties

Naphthalene is a two-ring hydrocarbon which forms a white crystalline powder. Naphthalene has a distinct and easily detectable odour (mothball odour), with mean and lowest air odour thresholds of 0.44 ± 9.95 and 0.01 mg/m³, respectively (Amoore and Hautala, 1983; Devos et al., 1990). Naphthalene is a by-product of combustion of biomass and fossil fuels (Jia and Batterman, 2010).

Detail	Properties
Molecular formula	C₁₀H₈
Molecular weight	128.17 g/mol
Vapour pressure	0.082 mm Hg at 25°C
Boiling point	217.9°C
Conversion factor	1 ppm = 5.24 mg/m³

Sources and concentrations in indoor environments

Naphthalene is present at detectable levels in residential environments and can arise from a wide array of sources, including consumer and building products such as paints, coatings, stains, solvents, adhesives, sealing products, flooring, carpeting, air fresheners, and pest control products (to kill moths and larvae) [Agency for Toxic Substances and Disease Registry, 2005; Health Canada, 2008].

As a product of incomplete combustion, naphthalene is emitted in cigarette smoke, during cooking, and from kerosene space heaters and wood stoves (Charles, Batterman and Jia, 2007; Moir et al., 2008; Jia and Batterman, 2010). Naphthalene in exhaust from vehicles and gas-powered equipment and in vapours from stored petroleum products in attached garages may infiltrate into occupied areas of the home (Marr et al., 1999; Schauer et al., 2002). Infiltration of outdoor air may also be a source of naphthalene in indoor air; however, ambient concentrations are generally lower than those found indoors.

Canadians’ exposure to naphthalene is attributed predominantly to indoor air, because indoor air levels generally exceed ambient air levels, and because of the greater time spent indoors. Inhalation of indoor air was identified as the greatest source of naphthalene exposure, accounting for more than 95.0% of the total daily intake across all age groups (Government of Canada, 2008).

Median concentrations of naphthalene measured in Canadian residences range from 0.2 to 1.6 µg/m³ and average concentrations from 0.3 to 6.3 µg/m³ (Fellin and Otson, 1994; Sanderson and Farant, 2004; Zhu et al., 2005; Héroux et al., 2008; Health Canada, 2010a; Health Canada, 2010b; Health Canada, 2012a; Health Canada, 2012b). Peak concentrations can reach values one to two orders of magnitude higher.

Health effects

Naphthalene has been shown to cause tissue damage and cancer in the nasal passages and lungs of rats and mice exposed to high levels of the substance in laboratory studies. It is considered a possible carcinogen for humans, although there is not yet sufficient evidence to prove it causes cancer in humans. Based on its potential cancer risk, and the margin between levels to which Canadians might be exposed and the critical effect level for non-cancer effects, naphthalene has been determined to meet the criteria under paragraph 64(c) of the Canadian Environmental Protection Act, 1999 (CEPA 1999).

In controlled exposure studies, Fischer 344 rats exposed to naphthalene for 6 hours/day, 5 days/week for 105 weeks showed increased nasal lesions at concentrations ranging from 52 to 314 mg/m³ (National Toxicology Program, 2000; Abdo et al., 2001). There are data that indicate a potential progression of effects from tissue damage in the nasal cavities and lungs potentially leading to the development of cancer.

There are data indicating a continuum of effects for acute, subchronic and chronic cytotoxicity and cancer in the rat nasal epithelium; subacute data are lacking for the mouse nose, although similar cytotoxic effects are seen acutely and chronically (National Toxicology Program, 2000). There is progression of acute to chronic lesions in the mouse lung; however, the lowest observed adverse effect levels (LOAELs) for pulmonary cytotoxicity in the mouse are higher than the rat nasal no observed adverse effect level (NOAEL) / lowest observed adverse effect level (West et al., 2001; Dodd et al., 2010).

There have also been reports of naphthalene exposure, from breathing it in, swallowing it or contact with skin, causing haemolytic anemia (a breakdown of red blood cells) [Dawson, Thayer and Desforges, 1958; Zinkham and Childs, 1958; Valaes, Doxiadis and Fessas, 1963; Naiman and Kosoy, 1964; Shannon and Buchanan, 1982; Ojwang, Ahmed-Jushuf and Abdullah, 1985; Ostlere, Amos and Wass, 1988; Owa et al., 1993; Santucci and Shah, 2000; Trevisan, Di Schio and Pieno, 2001; Lim, Poulose and Tan, 2009]. These reports primarily, but not always, involve people with glucose-6-phosphate dehydrogenase (G6PD) deficiency (a genetic deficiency that causes them to lack a specific enzyme that protects red-blood cells from naphthalene). Since there is no regular screening for this genetic condition, and there are no symptoms prior to exposure, people are unlikely to know that they have this genetic condition.

Prevention of acute and chronic nasal cytotoxicity is considered likely to prevent tumour development on chronic exposure. A short-term indoor air exposure limit was not considered necessary as a short-term reference concentration would be of a similar order of magnitude to the long-term reference concentration. Risk management measures to limit naphthalene exposure are the same for acute or chronic exposure.

Assessment under the Canadian Environmental Protection Act, 1999

Health Canada, in consultation with provincial and territorial health departments, developed a priority list of indoor air contaminants that were national in scope and required government action. Through this process, naphthalene was identified as an indoor air priority pollutant.

In 2008, under the Chemicals Management Plan, a screening assessment of naphthalene was published (Health Canada, 2008). On the basis of the carcinogenicity of naphthalene, and the margin between levels to which Canadians might be exposed and the critical effect level for non-cancer effects as well as the potential inadequacy of the margin between the upper-bounding concentration of naphthalene in indoor air and the critical effect level for non-cancer effects, the screening assessment concluded that naphthalene may be entering the environment in a quantity or concentration or under conditions that constitute or may constitute a danger in Canada to human life or health. Naphthalene was therefore determined to meet the criteria under paragraph 64(c) of the Canadian Environmental Protection Act, 1999.

Residential indoor air quality guideline for naphthalene

A long-term exposure limit for naphthalene in indoor air was derived based on the LOAEL of 52 mg/m³ from studies of rats exposed to naphthalene and screened for nasal lesions (National Toxicology Program, 2000). This value was then adjusted to account for the difference in the duration of exposure in the study compared to in a residence (i.e. from 6 hours/day × 5 days/week to 24 hours/day × 7 days/week). A total uncertainty factor of 1 000 was applied to the LOAEL to account for database deficiencies, interspecies and intra-individual variability (10 × 10 × 10 = 1 000).

The recommended long-term maximum exposure limit for naphthalene is presented in the table below, along with the critical health effects on which it was based. Exposure to indoor air concentrations above these limits may result in potential health effects. The minimum recommended sampling time is 24 hours.

Residential maximum exposure limit for naphthalene
Limits Exposure period	Concentration		Critical effects
Limits Exposure period	µg/m³	ppb	Critical effects
Long-term	10	1.9	Nasal lesions in rats

References

Abdo, K. M., Grumbein, S., Chou, B. J. and Herbert, R. (2001) “Toxicity and Carcinogenicity Study in F344 Rats Following 2 Years of Whole-Body Exposure to Naphthalene Vapors.” Inhalation Toxicology, 13(10), 931–950.

Agency for Toxic Substances and Disease Registry. (2005) Toxicological Profile for Naphthalene, 1-Methylnaphthalene, and 2-Methylnaphthalene, U.S. Department of Health and Human Services, Public Health Service, Atlanta, GA.

Amoore, J. E. and Hautala, E. (1983) “Odor As an Aid to Chemical Safety: Odor Thresholds Compared With Threshold Limit Values and Volatilities for 214 Industrial Chemicals in Air and Water Dilution.” Journal of Applied Toxicology, 3(6), 272–290.

Charles, S. M., Batterman, S. A. and Jia, C. (2007) “Composition and Emissions of VOCs in Main- and Side-Stream Smoke of Research Cigarettes.” Atmospheric Environment, 41(26), 5371–5384.

Dawson, J. P., Thayer, W. W. and Desforges, J. F. (1958) “Acute Hemolytic Anemia in the Newborn Infant Due to Naphthalene Poisoning: Report of Two Cases, With Investigations Into the Mechanism of the Disease.” Blood, 13(12), 1113–1125.

Devos, M., Patte, F., Rouault, J., Laffort, P. and Van Gemert, L. J. (1990) Standardized Human Olfactory Thresholds, IRL Press, Oxford, as cited in WHO (2010).

Dodd, D. E., Gross, E. A., Miller, R. A. and Wong, B. A. (2010) “Nasal Olfactory Epithelial Lesions in F344 and SD Rats Following 1- and 5-Day Inhalation Exposure to Naphthalene Vapor.” International Journal of Toxicology, 29(2), 175–184.

Fellin, P. and Otson, R. (1994) “Assessment of the Influence of Climatic Factors on Concentration Levels of Volatile Organic Compounds (VOCs) in Canadian Homes.” Atmospheric Environment, 28(22), 3581–3586.

Health Canada. (2008) Substance Profile for The Challenge — Naphthalene, CAS No. 91-20-3.

Health Canada. (2010a) Regina Indoor Air Quality Study 2007: VOC Sampling Data Summary.

Health Canada. (2010b) Windsor, Ontario, Exposure Assessment Study: VOC Sampling Data Summary (2005, 2006).

Health Canada. (2012a) Edmonton, Alberta, Exposure Assessment Study: VOC Sampling Data Summary (2010) [unpublished].

Health Canada. (2012b) Halifax, Nova Scotia, Exposure Assessment Study: VOC Sampling Data Summary (2010) [unpublished].

Héroux, M. È., Gauvin, D., Gilbert, N. L., Guay, M., Dupuis, G., Legris, M. and Lévesque, B. (2008) “Housing Characteristics and Indoor Concentrations of Selected Volatile Organic Compounds (VOCs) in Quebec City, Canada.” Indoor and Built Environment, 17(2), 128–137.

Jia, C. and Batterman, S. (2010) “A Critical Review of Naphthalene Sources and Exposures Relevant to Indoor and Outdoor Air.” International Journal of Environmental Research and Public Health, 7(7), 2903–2939.

Lim, H. C., Poulose, V. and Tan, H. H. (2009) “Acute Naphthalene Poisoning Following the Non-Accidental Ingestion of Mothballs.” Singapore Medical Journal, 50(8).

Marr, L. C., Kirchstetter, T. W., Harley, R. A., Miguel, A. H., Hering, S. V. and Hammond, S. K. (1999) “Characterization of Polycyclic Aromatic Hydrocarbons in Motor Vehicle Fuels and Exhaust Emissions.” Environmental Science and Technology, 33(18), 3091–3099.

Moir, D., Rickert, W. S., Levasseur, G., Larose, Y., Maertens, R., White, P. and Desjardins, S. (2008) “A Comparison of Mainstream and Sidestream Marijuana and Tobacco Cigarette Smoke Produced Under Two Machine Smoking Conditions.” Chemical Research in Toxicology, 21(2), 494–502.

Naiman, J. L. and Kosoy, M. H. (1964) “Red Cell Glucose-6-Phosphate Dehydrogenase Deficiency — A Newly Recognized Cause of Neonatal Jaundice and Kernicterus in Canada.” Canadian Medical Association Journal, 91(24), 1243–1249.

National Toxicology Program. (2000) NTP Technical Report on the Toxicology and Carcinogenesis Studies of Naphthalene (CAS No. 91-20-3) in F344/N Rats (Inhalation Studies), Rockville, MD.

Ojwang, P. J., Ahmed-Jushuf, I. H. and Abdullah, M. S. (1985) “Naphthalene Poisoning Following Ingestion of Moth Balls: Case Report.” East African Medical Journal, 62(1), 71–73.

Ostlere, L., Amos, R. and Wass, J. A. H. (1988) “Haemolytic Anaemia Associated With Ingestion of Naphthalene-Containing Anointing Oil.” Postgraduate Medical Journal, 64(752), 444–446.

Owa, J. A., Izedonmwen, O. E., Ogundaini, A. O. and Ogungbamila, F. O. (1993) “Quantitative Analysis of 1-Naphthol in Urine of Neonates Exposed to Mothballs: the Value in Infants With Unexplained Anaemia.” African Journal of Medicine and Medical Sciences, 22(1), 71–76, as cited in US EPA (2004, draft).

Sanderson, E. G. and Farant, J. P. (2004) “Indoor and Outdoor Polycyclic Aromatic Hydrocarbons in Residences Surrounding a Söerberg Aluminum Smelter in Canada.” Environmental Science and Technology, 38(20), 5350–5356.

Santucci, K. and Shah, B. (2000) “Association of Naphthalene With Acute Hemolytic Anemia.” Academic Emergency Medicine, 7(1), 42–47.

Schauer, J. J., Kleeman, M. J., Cass, G. R. and Simoneit, B. R. T. (2002) “Measurement of Emissions From Air Pollution Sources. 5. C₁–C₃₂ Organic Compounds From Gasoline-Powered Motor Vehicles.” Environmental Science and Technology, 36(6), 1169–1180.

Shannon, K. and Buchanan, G. R. (1982) “Severe Hemolytic Anemia in Black Children With Glucose-6-Phosphate Dehydrogenase Deficiency.” Pediatrics, 70(3), 364–369.

Canada Gazette, Part I, Volume 146, Number 41: GOVERNMENT NOTICES

DEPARTMENT OF HEALTH

CANADIAN ENVIRONMENTAL PROTECTION ACT, 1999

PROPOSED RESIDENTIAL INDOOR AIR QUALITY GUIDELINE FOR NAPHTHALENE

DEPARTMENT OF PUBLIC SAFETY AND EMERGENCY PREPAREDNESS

CRIMINAL CODE

DEPARTMENT OF PUBLIC SAFETY AND EMERGENCY PREPAREDNESS

CRIMINAL CODE

DEPARTMENT OF PUBLIC SAFETY AND EMERGENCY PREPAREDNESS

CRIMINAL CODE

DEPARTMENT OF PUBLIC SAFETY AND EMERGENCY PREPAREDNESS

CRIMINAL CODE